Peer-reviewed veterinary case report
Rapid test for diagnosing parvovirus and coronavirus in dogs
By Chaeyeong MIN et al.·Published in Korean Journal of Clinical Laboratory Science·2023·Department of Clinical Laboratory Science, Dong-eui University, Busan, Korea, KR·View original on DOAJ →
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Original publication title: Clinical Evaluation of a Rapid Diagnostic Test Kit for Canine Parvovirus and Coronavirus
- Species:
- dog
Plain-English summary
A dog showing signs of vomiting and diarrhea could be suffering from canine parvovirus or coronavirus, both of which are highly contagious and can cause serious gastroenteritis. A new rapid diagnostic test was evaluated for its effectiveness in quickly identifying these viruses in dogs. The test showed a high accuracy rate, with 90% sensitivity and 100% specificity, meaning it can reliably detect the viruses without confusion from other pathogens. This test can help veterinarians diagnose these conditions faster, which is crucial since there are no specific treatments available for these infections.
People also search for: dog vomiting diarrhea · canine parvovirus test · coronavirus in dogs symptoms
Abstract
Canine parvovirus type 2 (CPV-2) and canine coronavirus (CCoV) are major pathogens that can induce gastroenteritis in dogs. They are highly contagious and have a high morbidity rate. There are no specific treatments available for them to date. Therefore, rapid and accurate diagnosis becomes essential. The rapid diagnostic test (RDT) for animals can be used widely in the field because it is fast and easy to use for diagnosis. Thus, this study aimed to clinically evaluate and confirm the clinical utility of CPV-2/CCoV RDT. The parameters evaluated included the limit of detection (LoD), cross-reactivity, interference, sensitivity, specificity, negative likelihood ratio (NLR), and kappa value. The results revealed that the LoD values for CPV-2 and CCoV were 9.7×10 50% tissue culture infectious dose (TCID50)/mL and 2.5×102 TCID50/mL, respectively. There was no cross-reactivity with nine pathogens or interference by interfering materials. The RDT showed a sensitivity of 90.0%, a specificity of 100.0%, NLR of 0.1, and a kappa value of 0.90 for diagnosing both viruses. In conclusion, CPV-2/CCoV RDT is useful as a screening test because of its high sensitivity, specificity, kappa value, and low NLR.
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Search related cases →Original publication on DOAJ: https://doi.org/10.15324/kjcls.2023.55.1.45