Peer-reviewed veterinary case report
Phenylpropanolamine daily dose helps female dogs stop leaking urine
By Claeys, Stéphanie et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2011·Department of Clinical Sciences (Companion Animals)·View original on PubMed →
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Original publication title: Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch.
- Species:
- dog
Plain-English summary
A group of nine female dogs with a condition called urethral sphincter mechanism incompetence (USMI), which causes them to leak urine, were treated with a daily dose of phenylpropanolamine (PPA). After at least a month of treatment, eight out of the nine dogs were able to stay dry and showed improved bladder control. One dog didn’t respond to the medication and needed surgery instead. The treatment significantly increased the pressure needed to keep the urethra closed, helping the dogs maintain continence.
People also search for: dog urinary incontinence treatment · phenylpropanolamine for dogs · female dog leaking urine
Abstract
The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22043069/