Peer-reviewed veterinary case report
How misoprostol and aglepristone cause abortion in pregnant dogs
By Agaoglu, A R et al.·Published in Theriogenology·2014·Department of Obstetrics and Gynecology·View original on PubMed →
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Original publication title: Clinical evaluation of different applications of misoprostol and aglepristone for induction of abortion in bitches.
Plain-English summary
A group of 28 healthy pregnant dogs from various breeds and sizes were treated with different combinations of medications to induce abortion between 25 to 35 days of pregnancy. The treatments included injections and oral or vaginal medications of aglepristone and misoprostol. While there were no significant differences in how long it took for the abortions to occur across the different treatment groups, one dog in the group receiving vaginal misoprostol completed the abortion just two days after starting treatment. This suggests that while results can vary, some methods may work faster for certain dogs.
People also search for: dog abortion medication · misoprostol for dogs · aglepristone use in pregnant dogs
Abstract
The aim of the present study was to compare the clinical and endocrinological effects of different applications of misoprostol (MIS) and aglepristone (AGL) for the induction of abortion in bitches. For this purpose, 28 healthy pregnant bitches from different breeds, ages, body weights (Body weigt, BWs, 10-40 kg), and between Days 25 to 35 of gestation were used. Bitches were randomly assigned to four groups. In group 1 (GI, n = 7), AGL (10 mg/kg BW, s.c. on 2 consecutive days); in group 2 (GII, n = 7), AGL (as in GI), intravaginal MIS (IVag, 200 μg for bitches with ≤20 kg BW, 400 μg for bitches with >20 kg BW, daily intravaginally until completion of abortion); in group 3 (GIII, n = 7), AGL (as in GI), ICVag (as in GII), per os MIS (400 μg for bitches with ≤20 kg BW, 800 μg for bitches with >20 kg BW, daily orally, until completion of abortion); in group 4 (GIV, n = 7), AGL (as in GI), per os MIS (as GIII) were used. Clinical, vaginal, and ultrasonographic examinations were performed daily until abortion was completed. For measurement of serum progesterone, blood samples were collected in all groups immediately after the first AGL administration and every other day until completion of abortion. No statistical differences were found between groups concerning the duration until completion of abortion after treatment (nonsignificant); however, in GII, one bitch completed abortion 2 days after the start of treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24576713/