Peer-reviewed veterinary case report
Firocoxib vs carprofen for treating dog osteoarthritis pain
By Pollmeier, M et al.·Published in The Veterinary record·2006·Merial, Germany·View original on PubMed →
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Original publication title: Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis.
- Species:
- dog
Plain-English summary
A study involving 218 dogs with osteoarthritis compared two pain medications: firocoxib and carprofen. Both treatments were effective, with about 92% of dogs showing improvement after 30 days. However, dogs receiving firocoxib had a greater reduction in limping compared to those on carprofen. Owners reported that 96% of dogs on firocoxib improved, while 92% on carprofen did. This suggests that firocoxib may be a better option for managing pain in dogs with osteoarthritis.
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Abstract
A double-blind, randomised, controlled, multicentre field study was conducted to compare the safety and efficacy of firocoxib chewable tablets and carprofen tablets in 218 dogs with osteoarthritis. Firocoxib is a non-steroidal anti-inflammatory drug with more than 350-fold selectivity in dogs for the inducible isoform of the enzyme cyclo-oxygenase-2. The efficacy, tolerance and ease of administration of firocoxib (5 mg/kg/day) and carprofen (4 mg/kg/day) were assessed by the owners and the attending veterinarians during 30 days of treatment. The efficacy was assessed in terms of the dogs' overall scores at the end of the treatment, based on the veterinarians' assessment of lameness, pain on manipulation/palpation, range of motion, and joint swelling; 92.5 per cent of the dogs treated with firocoxib and 92.4 per cent of the dogs treated with carprofen had improved. The reduction in lameness in the dogs treated with firocoxib was significantly greater than in the dogs treated with carprofen. The owners' evaluations were that 96.2 per cent of the dogs treated with firocoxib and 92.4 per cent of the dogs treated with carprofen had improved, and this difference was statistically significant.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17056650/