Peer-reviewed veterinary case report
Pimecrolimus eye drops improve dry eye in dogs better than
By Ofri, Ron et al.·Published in Veterinary journal (London, England : 1997)·2009·Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: a comparison with cyclosporine A.
- Species:
- dog
Plain-English summary
A group of 44 dogs with dry eye (keratoconjunctivitis sicca) were treated with either pimecrolimus eye drops or cyclosporine A ointment for 8 weeks to see which worked better. The dogs receiving pimecrolimus showed a greater improvement in their eye inflammation and tear production compared to those on cyclosporine A. Both treatments were safe, but pimecrolimus was found to be more effective in helping the dogs feel more comfortable.
People also search for: dog dry eye treatment · pimecrolimus eye drops for dogs · cyclosporine A for dog eyes
Abstract
The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (+/-SEM) in the Schirmer tear test was 9.2+/-1.6 mm/min in the pimecrolimus group and 5.8+/-1.1 mm/min in the CsA group (P=0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA (P=0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17950639/