Peer-reviewed veterinary case report
Pituitary carcinoma with spread in an 11-year-old dog
By Nakaichi, Munekazu et al.·Published in The Journal of veterinary medical science·2020·Department of Veterinary Radiology, Japan·View original on PubMed →
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Original publication title: Clinical features and their course of pituitary carcinoma with distant metastasis in a dog.
- Species:
- dog
Plain-English summary
An 11-year-old male toy poodle was brought in with neurological symptoms and was found to have a large pituitary tumor that was producing a hormone called adrenocorticotropic hormone (ACTH). The dog underwent radiation therapy, which successfully controlled the tumor locally, but the hormone levels remained high. Further tests showed that the cancer had spread to the spleen, leading to surgery to remove the spleen. Unfortunately, the dog had multiple metastases to other abdominal organs, indicating that the cancer had spread significantly.
People also search for: dog neurological symptoms · pituitary tumor treatment in dogs · toy poodle cancer symptoms
Abstract
An 11-year-old male toy poodle with neurological symptoms was diagnosed with a macroscopic pituitary tumor, which produced adrenocorticotropic hormone. Radiation therapy with a linear accelerator was performed for the pituitary tumor, and resulted in good local tumor control. However, serum endogenous adrenocorticotropic hormone concentrations were uncontrollable even after the tumor disappeared. Abdominal computed tomography revealed splenic masses, and splenectomy was performed. Histopathological examination of the surgical specimen showed tumor cells with eosinophilic and finely granular cytoplasm suggestive of endocrine origin. Since these cells were positive for adrenocorticotropic hormone, the case was diagnosed as a pituitary carcinoma with distant metastasis. Necropsy revealed multiple metastases to the abdominal organs. This is the first case report describing canine pituitary carcinoma with distant metastasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33028750/