Peer-reviewed veterinary case report
Signs, diagnosis, and survival in dogs with brain glioma
By José-López, Roberto et al.·Published in Journal of veterinary internal medicine·2021·School of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Clinical features, diagnosis, and survival analysis of dogs with glioma.
- Species:
- dog
Plain-English summary
A group of 91 dogs diagnosed with brain tumors called gliomas were studied to understand their symptoms and survival rates. The research found that dogs receiving definitive treatments lived longer, with a median survival of 84 days, compared to just 26 days for those who only received palliative care. MRI scans showed that certain types of gliomas had distinct characteristics, which could help veterinarians better diagnose and classify these tumors. Unfortunately, gliomas generally have a poor prognosis, but knowing more about them can help in managing treatment options.
People also search for: dog brain tumor symptoms · glioma treatment for dogs · dog MRI brain tumor results
Abstract
BACKGROUND: Gliomas in dogs remain poorly understood. OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. ANIMALS: Ninety-one dogs with histopathological diagnosis of glioma. METHODS: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme. RESULTS: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45-190) compared to palliative treatment (26 days; 95% CI, 11-54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1-weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42-744.97; P = .04; OR, 45.5; 95% CI, 5.78-333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43-999.99; P = .02; OR, 32.3; 95% CI, 2.51-500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03-53.95; P = .049). Tumor spread to neighboring brain structures was associated with high-grade glioma (OR, 6.02; 95% CI, 1.06-34.48; P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34117807/