Peer-reviewed veterinary case report
Megakaryoblastic leukemia diagnosed in 10-year-old Shih-Tzu dog
By Park, Hee-Myung et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2006·Department of Veterinary Pathology, South Korea·View original on PubMed →
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Original publication title: Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old female Shih-Tzu was diagnosed with megakaryoblastic leukemia, a type of blood cancer. The diagnosis was confirmed through blood tests and special staining techniques that highlighted abnormal cells in her blood. These tests showed that the dog's body was producing too many immature blood cells, which can lead to serious health issues. Unfortunately, the abstract does not provide information on the treatment or outcome for this dog.
People also search for: dog leukemia symptoms · Shih-Tzu blood cancer treatment · what is megakaryoblastic leukemia in dogs
Abstract
The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using anti-human platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16789720/