Peer-reviewed veterinary case report
Dog developed hypothyroidism after long trimethoprim-sulfadiazine
By Gookin, J L et al.·Published in Journal of the American Veterinary Medical Association·1999·Department of Companion Animal and Special Species Medicine, United States·View original on PubMed →
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Original publication title: Clinical hypothyroidism associated with trimethoprim-sulfadiazine administration in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old spayed female mixed-breed dog developed symptoms of hypothyroidism, such as lethargy and weight gain, after being treated with a medication called trimethoprim-sulfadiazine for a long time. Tests showed her thyroid function was low, similar to natural hypothyroidism. Once the medication was stopped, her thyroid function returned to normal, and she made a full recovery.
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Abstract
Treatment of a 9-year-old spayed female mixed-breed dog with trimethoprim-sulfadiazine for a prolonged period resulted in clinical signs of hypothyroidism, and results of thyroid gland function tests were indistinguishable from those associated with endogenous hypothyroidism. Drug-induced hypothyroidism was diagnosed on the basis of history, normal thyroid uptake of sodium pertechnetate, and complete recovery of thyroid gland function after administration of trimethoprim-sulfadiazine was discontinued.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10200798/