Peer-reviewed veterinary case report
Bone infection in a dog caused by new Penicillium fungus species
By Langlois, Daniel K et al.·Published in Journal of clinical microbiology·2014·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clinical, morphological, and molecular characterization of Penicillium canis sp. nov., isolated from a dog with osteomyelitis.
- Species:
- dog
Plain-English summary
A young dog with a bone infection in the right hip was diagnosed with a rare type of mold called Penicillium canis. The dog was experiencing lameness, but after receiving intravenous treatment with a medication called amphotericin B, followed by a combination of terbinafine and ketoconazole, the dog's lameness improved and the infection stabilized. This case highlights the importance of identifying unusual infections in pets and the effective treatments available.
People also search for: dog lameness treatment · Penicillium infection in dogs · osteomyelitis in dogs treatment
Abstract
Infections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid-complexed amphotericin B initially, followed by long-term combination therapy with terbinafine and ketoconazole. A detailed morphological and molecular characterization of the mold was undertaken. Sequence analysis of the internal transcribed spacer revealed the isolate to be closely related to Penicillium menonorum and Penicillium pimiteouiense. Additional sequence analysis of β-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a novel species; the name Penicillium canis sp. nov. is proposed. Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on all media, and a failure to form ascomata distinguish this species from closely related Penicillium species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24789186/