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Peer-reviewed veterinary case report

Neurological signs and brain tumor in a 1-year-old Vizsla

By Bibbiani, Leonardo et al.·Published in Journal of the American Animal Hospital Association·2021·View original on PubMed

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Original publication title: Clinical, MRI, and Histopathological Features of Hypothalamic Neuronal Hamartoma in a Young Vizsla.

Species:
dog
Brain & nervesDogs

Plain-English summary

A 1-year-old female Vizsla was brought to the vet because she had been showing worsening neurological symptoms since she was adopted at 3 months old. An MRI revealed a non-cancerous growth in her brain called a hypothalamic neuronal hamartoma, which is a rare condition that doesn't spread. This case is the first of its kind reported in dogs, providing important information about how this condition appears in pets compared to humans. The dog’s symptoms were linked to this brain abnormality, and while specific treatments weren't detailed, understanding the condition can help guide future care.

Abstract

Human hypothalamic neuronal hamartomas are rare, nonprogressive, congenital malformations of the hypothalamus that do not expand or metastasize to other locations. A 1 yr old female vizsla was presented for progressive intracranial multifocal neurological signs present since adoption at 3 mo of age. MRI of the brain showed an ill-defined, intra-axial, space-occupying, nonenhancing lesion located in the ventral middle cranial fossa. Histopathological examination was consistent with hypothalamic neuronal hamartoma. This is the first report describing clinical, imaging, and histopathological features of a hypothalamic neuronal hamartoma in a dog. These findings are compared with their human counterparts.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33450014/