Peer-reviewed veterinary case report
Survival in dogs with bladder cancer treated with surgery and medicine
By Bradbury, Marcus L et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2021·Surgery Department, United States·View original on PubMed →
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Original publication title: Clinical outcomes of dogs with transitional cell carcinoma receiving medical therapy, with and without partial cystectomy.
- Species:
- dog
Plain-English summary
A group of dogs with urinary bladder cancer (transitional cell carcinoma) were treated either with surgery to remove part of the bladder and additional medical therapy or just with medical therapy alone. The dogs that had surgery along with medication lived longer on average—about 498 days compared to 335 days for those who only received medication. However, both groups had similar times before the cancer progressed. This suggests that while surgery may improve overall survival, more research is needed to fully understand its benefits.
People also search for: dog bladder cancer treatment · transitional cell carcinoma in dogs · dog surgery for bladder cancer
Abstract
The objective of this retrospective study was to evaluate the effects of surgery on outcome for dogs with naturally occurring urinary bladder transitional cell carcinoma. Forty-seven dogs met the inclusion criteria. Thirty-one dogs (Group A) were treated with partial cystectomy and adjunctive medical therapy and 16 dogs (Group B) were treated with medical therapy alone. Overall survival was greater in dogs treated with partial cystectomy and adjunctive medical therapy (498 days for Group A335 days for Group B, hazard ratio 2.5; 95% confidence interval: 1.1 to 5.7;= 0.026). Progression-free survival was not different between groups (85 days for Group A83 days for Group B;= 0.663). No prognostic factors were identified for progression-free survival. Due to the many cases in Group A that were lost to follow-up, time-to-event survival analysis was performed. No significant difference in overall survival was noted, and no prognostic factors were identified in the time-to-event analysis. Prospective, randomized studies are needed to determine the role of partial cystectomy in the treatment of transitional cell carcinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33542551/