Peer-reviewed veterinary case report
Canine high-grade olfactory neuroblastoma diagnosis and treatment
By Church, Molly E et al.·Published in Veterinary and comparative oncology·2019·Department of Pathobiology, United States·View original on PubMed →
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Original publication title: Clinical outcomes, ultrastructure and immunohistochemical features of canine high-grade olfactory neuroblastoma.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with a rare type of nasal tumor called olfactory neuroblastoma (ONB) after showing signs of nasal obstruction. The dog underwent surgery to remove as much of the tumor as possible, followed by radiation therapy. This treatment approach, similar to what is used in humans, helped the dog survive longer than expected despite the advanced stage of the disease. The study highlighted that radiation therapy can be effective for dogs with this condition, potentially improving their quality of life.
People also search for: dog nasal tumor treatment · olfactory neuroblastoma in dogs · dog radiation therapy for cancer
Abstract
Olfactory neuroblastoma (ONB) is a rare intranasal neoplasm in both dogs and humans. Similar clinical presentation and overlapping histologic and immunohistochemical features of ONB with other intranasal neoplasms can make diagnosis and treatment of intranasal neoplasia challenging. Furthermore, in part because of their rarity, there is a lack of reporting on therapeutic regimen for these neoplasms. In humans, initial debulking surgery is usually followed by radiation therapy. Here we report on the histologic, immunohistochemical, and ultrastructural characteristics of canine ONB and report on the clinical progression of cases treated with radiation therapy. In all nine canine ONB examined here, neoplastic cells were arranged in a lobular manner amidst a prominent neurofibrillary matrix and had features consistent with Grade III (high grade) ONB. The neoplastic cells demonstrated positive immunohistochemical staining for TuJ-1, a Class III beta-tubulin neuronal cytoskeletal protein, and variable staining for other markers, including chromogranin, synaptophysin, AE1/AE3 and MAP2. The longest surviving case was treated with a regimen similar to that used in humans, consisting of debulking surgery followed by definitive radiation therapy. Our study found that TuJ-1 is a useful marker for ONB and that radiation therapy, even in cases of advanced disease, may result in prolonged survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31177641/