Peer-reviewed veterinary case report
Multiple skin tumors in an adult cow diagnosed as mast cell tumors
By Chevallier, Lucie et al.·Published in Veterinary clinical pathology·2024·INSERM, France·View original on PubMed →
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Original publication title: Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow.
- Species:
- dog
Plain-English summary
A 11-year-old Prim'Holstein cow was brought in because she had multiple skin nodules for the past five months. Tests confirmed that these nodules were mast cell tumors, which are rare in cattle. The cow received corticosteroid treatment, but unfortunately, her condition did not improve enough, and euthanasia was chosen. After her passing, further examinations showed that the tumors had not spread to other organs.
People also search for: cow skin nodules · mast cell tumor treatment in cattle · why does my cow have lumps on her skin
Abstract
Cutaneous mast cell tumors are rarely reported in cattle. Although mutations in the c-KIT gene have been shown to play a central role in the oncogenesis of canine mast cell tumors, few data are available in cattle. This report describes the clinical, histologic, immunohistochemical, and genetic features of a multicentric cutaneous mast cell tumor in an adult cow. An 11-year-old Prim'Holstein cow was presented for a 5-month history of multiple skin nodules. Cytologic and histologic analyses of the nodules led to a diagnosis of mast cell tumors. Immunohistochemical analysis for KIT expression showed a moderate to strong signal in neoplastic mast cells with a cytoplasmic and membranous pattern. Sequencing of the c-KIT gene coding sequence revealed no mutation. Despite partial response after corticosteroid treatment, euthanasia was elected. No metastases to the lymph nodes, spleen, and liver were identified at post-mortem and histologic examinations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38418393/