Peer-reviewed veterinary case report
Blood and immune markers linked to atopic dermatitis in dogs
By Martins, Guilherme De Caro et al.·Published in Veterinary immunology and immunopathology·2018·Departamento de Clí, Brazil·View original on PubMed →
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Original publication title: Clinical-pathological and immunological biomarkers in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a chronic skin condition causing itching) showed changes in their blood and immune system that could help track the disease. The study found that these dogs had higher levels of certain white blood cells, which are involved in inflammation and immune responses. This information could help veterinarians monitor the severity of the condition and adjust treatments accordingly. Identifying these biomarkers may lead to better management of atopic dermatitis in dogs, helping them feel more comfortable.
People also search for: dog itching treatment · atopic dermatitis in dogs · dog skin allergy symptoms
Abstract
Canine atopic dermatitis (CAD) is a chronic, pruritic, genetic, and inflammatory disease. Its pathogenesis is very complex and involves skin barrier defects and immune system dysfunction. This study aimed to investigate hematological, biochemical, clinical, and immunological parameters to contribute to the identification of biomarkers applied to CAD. The results of the analysis on hematologic and clinical parameters showed increased neutrophil numbers and decreased lymphocyte counts. The ex vivo immunophenotyping of leukocytes demonstrated increased counts of circulating neutrophils, in addition to a high frequency of CD4T-cells and elevated CD4/CD8T-cell ratio, which were the hallmark of atopic animals. Moreover, atopic dogs presented a mixed immune response, displaying both CD4and CD8T-cell subsets as relevant sources of IFN-γ and IL-4 cytokines. The morbidity analyzed by the CADESI index demonstrated that CAD severity is related to the low frequency of circulating CD14monocytes, CD21B-cells, and CD8T-cells. The reported biomarkers would be useful in CAD monitoring for treatment and prognosis analysis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30459002/