Peer-reviewed veterinary case report
Accuracy of rapid Coccidioides antibody test in dogs
By Reagan, Krystle L et al.·Published in Journal of veterinary internal medicine·2021·Department of Medicine and Epidemiology, United States·View original on PubMed →
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Original publication title: Clinical performance of a point-of-care Coccidioides antibody test in dogs.
- Species:
- dog
Plain-English summary
A group of dogs suspected of having coccidioidomycosis (a fungal infection) were tested using a new rapid antibody test to see how well it worked compared to the standard lab test. Out of 48 dogs, the new test correctly identified 32 of 36 dogs that had the infection and all 12 that did not. This means the new test is quite reliable, especially for confirming positive cases, but if a dog has low levels of infection, further testing is advised. Overall, the rapid test could help vets diagnose this condition more quickly.
People also search for: dog coccidioidomycosis symptoms · rapid test for dog fungal infection · coccidioidomycosis treatment in dogs
Abstract
BACKGROUND: Point-of-care (POC) Coccidioides antibody assays may provide veterinarians with rapid and accurate diagnostic information. OBJECTIVES: To determine the agreement of a POC lateral flow assay (LFA), sona Coccidioides (IMMY, Norman, Oklahoma) with the current diagnostic standard, the immunodiffusion assay (agar gel immunodiffusion [AGID]; Coccidioidomycosis Serology Laboratory, University of California, Davis, California). ANIMALS: Forty-eight sera specimens from 48 dogs. METHODS: Sera specimens were collected from client-owned dogs that had a clinical suspicion for coccidioidomycosis. Animals were classified as Coccidioides antibody-positive (n = 36) based on a positive AGID or Coccidioides antibody-negative (n = 12) based on a negative AGID. The performance of the LFA assay was determined by comparing results to AGID results. RESULTS: The LFA assay demonstrated agreement in 32 of 36 Coccidioides antibody-positive specimens and 12 of 12 Coccidioides antibody-negative specimens, resulting in a positive percentage agreement of 88.9% (95% confidence interval [CI], 74.7-95.6%) and negative percentage agreement of 100% (95% CI, 75.8-100%) as compared to AGID. A receiver operator characteristic curve was constructed, and the area under the curve was 0.944 (CI, 0.880-1.000). CONCLUSION AND CLINICAL IMPORTANCE: This LFA is a rapid alternative to the traditional AGID. The LFA provides excellent predictive value for positive results. Positive agreement was lower in dogs with low AGID titers; therefore, confirmatory testing is recommended if a high index of suspicion exists.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33675146/