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Peer-reviewed veterinary case report

Puppy with vomiting and lethargy after ribavirin overdose

By Bridges, Kimberly et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2016·Tufts Cummings School of Veterinary Medicine, United States·View original on PubMed

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Original publication title: Clinical presentation and management of suspected ribavirin toxicosis in a dog.

Species:
dog

Plain-English summary

A 5-month-old pit bull terrier was brought in after showing signs of extreme tiredness, vomiting, diarrhea, and not wanting to eat, 45 hours after accidentally swallowing a large amount of the antiviral medication ribavirin. The vet found the dog was dehydrated and had a fast heart rate, along with liver issues. After 5 days of intensive care that included IV fluids, medications to stop vomiting, and support for the liver, the dog was sent home and started to recover.

People also search for: dog vomiting and diarrhea after medication · pit bull lethargy treatment · ribavirin poisoning in dogs

Abstract

A 5-month-old pit bull terrier was presented for evaluation of progressive lethargy, vomiting, diarrhea, and anorexia 45 hours after ingestion of 625 mg/kg body weight (BW) (9000 mg) of the antiviral medication, ribavirin. Abnormalities that were detected included dehydration, tachycardia, elevated liver enzymes, and prolonged prothrombin time. The dog was discharged after 5 days of aggressive supportive care consisting of intravenous fluids, antiemetics, gastroprotectants, hepatoprotectants, dextrose supplementation, and vitamin B/K1 supplementation.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27152039/