Peer-reviewed veterinary case report
Signs and outcomes of immune-mediated polyarthritis in dogs in France
By Cervone, Mario et al.·Published in Veterinary journal (London, England : 1997)·2025·Université, France·View original on PubMed →
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Original publication title: Clinical presentation, diagnostic findings, and outcome in dogs with presumptive primary and reactive immune-mediated polyarthritis in France.
- Species:
- dog
Plain-English summary
A group of dogs with joint swelling, pain, and heat were diagnosed with immune-mediated polyarthritis, a condition where the immune system attacks the joints. Blood tests showed many had anemia and high levels of inflammation markers. Most of these dogs improved significantly, with about 74% achieving complete remission within an average of 37 days after starting treatment. Monitoring certain blood proteins may help predict how quickly a dog will recover.
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Abstract
Limited data exist regarding immune-mediated polyarthritis in dogs, particularly regarding reactive immune-mediated polyarthritis. The aim of this study was to describe the clinical presentations, the diagnostic findings, and the outcome of dogs diagnosed with presumptive primary and reactive immune-mediated polyarthritis in France, and to evaluate potential biomarkers for assessing treatment response. Medical records were retrospectively reviewed for dogs diagnosed with immune-mediated polyarthritis between June 2004 and January 2020. Fifty-eight dogs were included, of which 43 diagnosed with primary and 15 with reactive immune-mediated polyarthritis. Associated diseases in dogs with reactive immune-mediated polyarthritis included leishmaniosis (7), digestive disorders (3), eosinophilic bronchopneumopathy (3), bacterial infection (1), and gossypiboma (1). Overall, dogs showed a combination of joint swelling, pain, or heat. Anaemia (30 %), leucocytosis (47 %), high serum CRP (90 %) and low serum albumin (61 %) concentrations were the most frequent bloodwork abnormalities. Most dogs (74 %) experiencing complete clinical remission, and the mean time to remission was 37 days. Serum albumin, total proteins and globulins concentrations appeared as potential predictors for the time to remission. Clinical presentation and diagnostic features are not specific in dogs with immune-mediated polyarthritis. Overall, most dogs achieve clinical remission, but the time to achieve remission may be long. Serum albumin, total proteins and globulins concentrations may be predictors for the time to remission.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40222410/