Peer-reviewed veterinary case report
Prognostic factors for survival in dogs with histiocytic sarcoma
By Dervisis, N G et al.·Published in Veterinary and comparative oncology·2017·VA-MD College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Clinical prognostic factors in canine histiocytic sarcoma.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with histiocytic sarcoma, an aggressive type of cancer, had their medical records reviewed to understand how different factors affected their survival. The study included breeds like Bernese mountain dogs, Labrador retrievers, and golden retrievers, with an average survival time of about 170 days. It was found that dogs receiving palliative care, those with widespread cancer, and those treated with corticosteroids had shorter survival times. This information can help pet owners understand the seriousness of this condition and the impact of treatment choices.
People also search for: dog histiocytic sarcoma prognosis · Bernese mountain dog cancer treatment · Labrador retriever cancer survival rate
Abstract
Canine histiocytic sarcoma (HS) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort of canine patients with immunohistochemically confirmed HS and identify clinical prognostic factors. Biopsy submissions to the Michigan State University with tentative HS diagnoses were histologically and immunohistochemically confirmed, medical records collected, and interviews with relevant veterinary clinics conducted. Of 1391 histopathology submissions with a diagnosis containing the word 'histiocytic', 335 were suspicious for malignancy, and 180 were consistent with HS and had adequate clinical information recorded. The most commonly represented breeds were Bernese mountain dogs (n = 53), labrador retrievers (n = 26) and golden retrievers (n = 17). Median survival for all dogs in the study was 170 days, and subgroup analysis identified palliative treatment, disseminated HS, and concurrent use of corticosteroids as statistically significant negative factors for survival, in both uni- and multi-variate methodologies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27334037/