Peer-reviewed veterinary case report
Irish setter puppies with immune deficiency show bone and lung
By Trowald-Wigh, G et al.·Published in The Journal of small animal practice·2000·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Clinical, radiological and pathological features of 12 Irish setters with canine leucocyte adhesion deficiency.
- Species:
- dog
Plain-English summary
Twelve Irish Setter puppies under 15 weeks old were brought in with serious health issues, including fever, swollen lymph nodes, and gum disease. Most had been treated with antibiotics for infections, and many showed signs of respiratory distress. X-rays revealed bone problems, and despite treatment, all the puppies had to be euthanized before six months due to severe infections linked to a condition called canine leucocyte adhesion deficiency (CLAD), which affects their immune response. The diagnosis was confirmed through specialized blood tests.
People also search for: Irish Setter puppy fever · CLAD in dogs · puppy gum disease treatment · dog respiratory distress symptoms · canine leucocyte adhesion deficiency signs
Abstract
The clinical, radiological and pathological findings in 12 dogs with canine leucocyte adhesion deficiency (CLAD) from six litters are described. All the dogs were younger than 15 weeks at admission, all had been febrile and 11 had been treated with antibiotics. Seven had been treated for omphalophlebitis. At admission, all had gingivitis, lymph node enlargement and profound neutrophilia. Ten dogs were radiographed and showed various skeletal lesions compatible with metaphyseal osteopathy, craniomandibular osteopathy and osteomyelitis. Four dogs had clinical signs of respiratory distress and seven exhibited a mild interstitial pneumonia at necropsy. Six dogs had skin wounds, with strikingly few neutrophils seen on stained sections. All dogs were euthanased before six months of age due to severe and incurable infections. The clinical signs, radiological features and haematology were strongly suggestive of CLAD. The diagnosis was confirmed by granulocyte function tests and flow cytometry, which revealed impaired adhesion, impaired C3b-mediated phagocytosis and absence of adhesion proteins CD11b/CD18.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10907223/