Peer-reviewed veterinary case report
Single-dose ear drop treatment for dog ear infections works well
By Heuer, Lea et al.·Published in The Veterinary record·2024·MSD Animal Health Innovation, Germany·View original on PubMed →
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Original publication title: Clinical safety and efficacy of a single-dose gentamicin, posaconazole and mometasone furoate otic suspension for treatment of canine otitis externa.
- Species:
- dog
Plain-English summary
A group of dogs with ear infections (otitis externa) were treated with a new single-dose medication that combines gentamicin, posaconazole, and mometasone furoate. After 28 days, 89.5% of the dogs treated with this new product showed significant improvement, which was comparable to a control treatment given twice. This new treatment not only helped clear the infection but also made it easier for pet owners, as they only needed to administer it once. Overall, it proved to be a safe and effective option for dogs suffering from painful ear infections.
People also search for: dog ear infection treatment · single-dose ear drops for dogs · how to treat otitis externa in dogs
Abstract
BACKGROUND: A single-dose, in-clinic, veterinary professional-administered treatment for canine otitis externa was developed to improve compliance and canine welfare. METHODS: This multicentre, controlled, examiner-masked, randomised field trial was conducted in 316 dogs over 42 days. Dogs were treated once, on day 0, with the investigational product containing gentamicin, posaconazole and mometasone furoate (Mometamax Ultra [MU]) or twice (days 0 and 7) with a control product containing florfenicol, terbinafine and betamethasone acetate (CP). The primary endpoint was a composite otitis index score of 4 or less (of 12) on day 14 and 3 or less (of 12) on day 28. RESULTS: On day 28, treatment success was recorded in 128 of 143 MU-treated dogs (89.5%), significantly non-inferior to 116 of 133 (87.2%) CP-treated dogs (Farrington-Manning test, Z = 4.1351, p < 0.0001). For mixed cultures of Staphylococcus pseudintermedius and Malassezia pachydermatis, there was 100% treatment success in MU-treated dogs (n = 33), significantly non-inferior to 90.2% (37 of 41) in CP-treated dogs (Farrington-Manning test, Z = 3.1954, p = 0.0007). LIMITATIONS: Efficacy in chronic otitis externa cases was not investigated. Cytology was not used to aid in diagnosis or for identification of secondary pathogens. CONCLUSION: This unique combination, single-dose product is safe and effective in dogs with otitis externa. It offers enhanced compliance, canine welfare and quality of life by eliminating the owner burden of treating this painful condition.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38462781/