Peer-reviewed veterinary case report
Cyclosporine helps reduce itching in dogs with atopic dermatitis
By Steffan, Jean et al.·Published in Journal of the American Veterinary Medical Association·2005·Novartis Animal Health·View original on PubMed →
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Original publication title: Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 268 dogs with atopic dermatitis (a skin condition causing severe itching) was treated with cyclosporine, a medication that helps reduce inflammation and itching. After 16 weeks, many dogs showed significant improvement, with 68% having a marked reduction in their skin condition and 47% experiencing little to no itching. The treatment was generally well tolerated, although some dogs had mild stomach issues. This suggests that cyclosporine can be an effective option for managing atopic dermatitis in dogs.
People also search for: dog itching treatment · cyclosporine for dog skin problems · atopic dermatitis in dogs treatment
Abstract
OBJECTIVE: To determine efficacy and safety of cyclosporine in the treatment of atopic dermatitis among dogs in North America. DESIGN: Randomized controlled (phase 1) and open-label (phase 2) trials. ANIMALS: 268 dogs with atopic dermatitis. PROCEDURE: In phase 1, dogs were randomly assigned to be treated with cyclosporine (5 mg/kg [2.3 mg/Ib], PO, q 24 h) or a placebo. In phase 2, all dogs were treated with cyclosporine for 16 weeks. Frequency of cyclosporine administration was decreased if dogs improved clinically. RESULTS: At the end of phase 1, canine atopic dermatitis extent and severity index (CADESI) scores for dogs treated with cyclosporine were significantly lower than scores for control dogs. Percentage of dogs with severe pruritus decreased from 67% to 16% for the cyclosporine group but from 66% to only 61% for the control group. During phase 2, cyclosporine dosage was decreased to every-other-day administration in 39% of the dogs after 4 weeks. After 12 weeks, 22% of the dogs were treated twice weekly and 36% were treated every other day. After 16 weeks, CADESI score had decreased > 50% in 68% of the dogs and 47% of dogs had no or mild pruritus. The most frequent adverse reactions were gastrointestinal tract signs. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that cyclosporine is efficacious for the treatment of atopic dermatitis in dogs and that frequency of cyclosporine administration can be reduced following an initial induction period. The drug was well tolerated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15934253/