Peer-reviewed veterinary case report
Vinblastine treatment results for dogs with bladder cancer
By Arnold, E J et al.·Published in Journal of veterinary internal medicine·2011·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Clinical trial of vinblastine in dogs with transitional cell carcinoma of the urinary bladder.
- Species:
- dog
Plain-English summary
A group of 28 dogs with transitional cell carcinoma (TCC) of the urinary bladder received vinblastine, a chemotherapy drug, to see if it could help shrink their tumors. About 36% of the dogs showed partial improvement, while half had stable disease, meaning their cancer didn’t get worse. Most dogs tolerated the treatment well, with only one needing significant adjustments due to low white blood cell counts. On average, dogs lived about 147 days after starting vinblastine, suggesting it can be a viable option for treating this challenging cancer in dogs.
People also search for: dog bladder cancer treatment · vinblastine for dog cancer · transitional cell carcinoma in dogs
Abstract
BACKGROUND: Transitional cell carcinoma (TCC) of the urinary bladder of dogs can be a difficult cancer to treat, and effective therapies are limited. Vinblastine has been used in humans with TCC and has potent anti-proliferative effects against canine TCC cells in vitro. OBJECTIVES: To determine the antitumor activity and toxicoses of vinblastine in dogs with urinary bladder TCC. ANIMALS: Animals selected were 28 privately owned dogs that presented to the Purdue University Veterinary Teaching Hospital (PUVTH) with measurable, histologically confirmed TCC. METHODS: Prospective clinical trial: The starting vinblastine dosage was 3.0 mg/m(2) i.v. every 2 weeks. Treatment continued until cancer progression or unacceptable toxicoses occurred. Complete evaluations (physical exam, complete blood count [CBC], serum biochemical profile, urinalysis, thoracic radiography, abdominal ultrasound [US]) were performed at 8-week intervals. Urinary tract US with bladder tumor mapping was performed monthly. Toxicoses were graded according to Veterinary Co-Operative Oncology Group (VCOG) criteria. RESULTS: Tumor responses included 10 (36%) partial remission, 14 (50%) stable disease, and 4 (14%) progressive disease. The median progression free interval was 122 days (range, 28-399 days). The median survival time was 147 days (range, 28-476 days) from 1st vinblastine treatment to death and 299 days (range, 43-921 days) from diagnosis to death. The majority of dogs (27 of 28) did not have clinically relevant adverse effects. Seventeen of 28 (61%) dogs required dosage reductions because of neutropenia. CONCLUSION AND CLINICAL IMPORTANCE: Vinblastine has antitumor activity against TCC in dogs and can be considered another treatment option for this cancer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22092632/