Peer-reviewed veterinary case report
Ceramide moisturizer helps dogs with atopic dermatitis itching
By Jung, Ji-young et al.·Published in Journal of veterinary science·2013·College of Veterinary Medicine and Research Institute for Veterinary Science, South Korea·View original on PubMed →
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Original publication title: Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 20 dogs aged 3 to 8 years with atopic dermatitis (a skin condition causing itching and irritation) were treated with a ceramide-based moisturizer for four weeks. Owners noticed improvements in their dogs' skin hydration and a decrease in itching and severity of skin issues. Tests showed that the skin barrier was partially restored, indicating the moisturizer was effective in treating the symptoms of atopic dermatitis. Most dogs experienced significant relief and healthier skin by the end of the treatment period.
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Abstract
In humans, skin barrier dysfunction is thought to be responsible for enhanced penetration of allergens. Similar to conditions seen in humans, canine atopic dermatitis (CAD) is characterized by derangement of corneocytes and disorganization of intercellular lipids in the stratum corenum (SC) with decreased ceramide levels. This study was designed to evaluate the effects of a moisturizer containing ceramide on dogs with CAD. Dogs (n = 20, 3~8 years old) with mild to moderate clinical signs were recruited and applied a moisturizer containing ceramide for 4 weeks. Transepidermal water loss (TEWL), skin hydration, pruritus index for canine atopic dermatitis (PICAD) scores, and canine atopic dermatitis extent and severity index (CADESI) scores of all dogs were evaluated. Skin samples from five dogs were also examined with transmission electron microscopy (TEM) using ruthenium tetroxide. TEWL, PICAD, and CADESI values decreased (p < 0.05) and skin hydration increased dramatically over time (p < 0.05). Electron micrographs showed that the skin barrier of all five dogs was partially restored (p < 0.05). In conclusion, these results demonstrated that moisturizer containing ceramide was effective for treating skin barrier dysfunction and CAD symptoms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23814473/