Peer-reviewed veterinary case report
Peripheral odontogenic fibromas in dogs and diagnosis risks
By Ambridge, J T et al.·Published in The Journal of small animal practice·2023·Department of Veterinary Pathology·View original on PubMed →
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Original publication title: Clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their laboratory diagnosis.
- Species:
- dog
Plain-English summary
A group of dogs, particularly Boxers, Border Terriers, and Basset Hounds, were found to develop peripheral odontogenic fibromas, which are growths in the mouth, more frequently than other breeds. These fibromas were most commonly located in the upper jaw and were more likely to occur in male dogs and those that had been neutered. The average age of diagnosis was around 8 years. Understanding which breeds are at higher risk can help veterinarians diagnose and treat these growths more effectively.
People also search for: dog mouth growths · Boxer peripheral odontogenic fibroma · neutered dog oral tumors · Border Terrier dental issues
Abstract
OBJECTIVES: To explore clinicopathological features of peripheral odontogenic fibromas in dogs and risk factors for their diagnosis. MATERIALS AND METHODS: Data of cases with a histopathological diagnosis of peripheral odontogenic fibromas were obtained from a UK-based diagnostic laboratory and retrospectively reviewed. Prevalence amongst all biopsy submissions was assessed using binomial tests and Clopper-Pearson intervals. Age at diagnosis was assessed using t-test for independent samples. Lesion location, sex, and neuter status were assessed using χand post hoc binomial tests. Breed odds ratios were calculated using univariable logistic regression modelling. RESULTS: The prevalence of peripheral odontogenic fibromas amongst all biopsy submissions was 2.8% (1001 of 35,328, 95% confidence interval [CI]: 2.7 to 3.0). The mean (sd) age was 8.1 (±2.7) years. The most affected quadrant was the rostral maxilla (40.1%). The ratio of maxillary to mandibular lesions was 1.3:1 (95% CI: 1.1 to 1.5), and for cases of multiple peripheral odontogenic fibromas the ratio of maxillary to mandibular lesions was 2.4:1 (95% CI: 1.1 to 5.6). Males had 1.2 times the odds of suffering of peripheral odontogenic fibromas compared to females (odds ratio [OR]: 1.2, 95% CI: 1.1 to 1.4). Neutering was associated with an increased risk of diagnosis (OR: 1.6, 95% CI: 1.3 to 1.9). Breeds with increased odds of peripheral odontogenic fibromas compared to crossbreed dogs included boxers (OR: 3.78, 95% CI: 2.80 to 5.09), border terriers (OR: 3.21, 95% CI: 2.10 to 4.91) and Basset Hounds (OR: 3.18, 95% CI: 1.58 to 6.44). Breeds with increased odds of multiple simultaneous peripheral odontogenic fibromas compared to crossbreed dogs included: Boxers (OR: 12.02, 95% CI: 7.13 to 20.24), border terriers (OR: 5.05, 95% CI: 2.32 to 11.43) and Staffordshire Bull terriers (OR: 2.42, 95% CI: 1.33 to 4.41). CLINICAL SIGNIFICANCE: Knowledge of clinicopathological features and at-risk breeds for peripheral odontogenic fibroma development can assist clinicians with making a diagnosis. The identification of risk factors provides targets for future research investigating peripheral odontogenic fibroma pathogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36782367/