Peer-reviewed veterinary case report
Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.
- Journal:
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Year:
- 2009
- Authors:
- Ando, Hitoshi et al.
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- rodent
Abstract
Recent studies have revealed a close relationship between the pathophysiology of metabolic syndrome, which is characterized by obesity and hyperglycemia, and the functioning of internal molecular clocks. In this study, we show that the rhythmic mRNA expression of clock genes (Clock, Bmal1, Cry1, and Dbp) is not attenuated in the liver and visceral adipose tissues of Goto-Kakizaki rats, a model of nonobese, type 2 diabetes, as compared to control Wistar rats. Our results suggest that molecular clock impairment in peripheral tissues of obese diabetic animals may be either caused by obesity-related factor(s), but not hyperglycemia, or be a cause, but not a consequence, of hyperglycemia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19387896/