Peer-reviewed veterinary case report
Detecting canine lymphoma cells before and after chemo using PCR
By Thilakaratne, Dilini N et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2010·Department of Veterinary Pathology, Canada·View original on PubMed →
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Original publication title: Clonality and phenotyping of canine lymphomas before chemotherapy and during remission using polymerase chain reaction (PCR) on lymph node cytologic smears and peripheral blood.
- Species:
- dog
Plain-English summary
A group of 10 dogs with lymphoma (a type of cancer affecting the lymph nodes) underwent tests to check the presence of cancer cells before starting chemotherapy and during their remission period. The tests showed that 7 of these dogs had clonal cancer cells, meaning the cancer was present in a specific form, even after treatment. Interestingly, 6 of the dogs still showed signs of these clonal cells during remission, indicating that some cancer cells might remain in the body. This finding suggests that further research is needed to see if detecting these residual cancer cells can help predict how well the dogs will do in the future.
People also search for: dog lymphoma treatment · signs of lymphoma in dogs · dog cancer remission testing
Abstract
Polymerase chain reaction (PCR) assays for the immunoglobulin and T-cell receptor genes were utilized to determine phenotype and clonality from lymph node cytologic smears and peripheral blood lymphocytes from 10 dogs with lymphoma, before chemotherapy and during remission. Results were compared with those from 13 dogs with a cytologic diagnosis of lymph node hyperplasia. Clonality was identified in 7 of the lymphomas on the basis of either lymph node cytology or peripheral blood lymphocytes before treatment. No lymph node hyperplasia samples were clonal. In 6 of the dogs with lymphoma, clonality was demonstrated during clinical remission. Detection of PCR clonality during clinical remission is an effective means of identifying minimal residual disease in canine lymphoma and thus additional work is warranted to determine if molecular remission is prognostic or predictive for outcome in well-controlled and well-defined lymphoma subtypes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20357946/