Peer-reviewed veterinary case report
Blood clotting problems in dogs with liver disease
By Prins, M et al.·Published in Veterinary journal (London, England : 1997)·2010·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Coagulation disorders in dogs with hepatic disease.
- Species:
- dog
Plain-English summary
A group of dogs with liver disease were tested for blood clotting problems, and it was found that over half had some form of coagulation abnormality. Specifically, dogs with chronic hepatitis and cirrhosis had longer clotting times and lower platelet counts compared to those with other liver issues. This suggests that liver disease can affect the body's ability to stop bleeding, particularly in cases of cirrhosis. Treatment options would depend on the specific liver condition, and it's important for pet owners to monitor their dogs for any signs of bleeding or bruising.
People also search for: dog liver disease symptoms · dog blood clotting problems · chronic hepatitis in dogs · dog cirrhosis treatment
Abstract
Liver disease has been associated with abnormalities in haemostasis. In this study, coagulation times, platelet counts, platelet activity parameters, activities of individual coagulation factors, D-dimers, antithrombin (AT) and protein C activity were measured in 42 dogs with histologically confirmed liver disease. Outcome was correlated with histological diagnosis. One or more coagulation abnormalities were present in 57% of dogs with hepatic disease. Activated partial thromboplastin time was significantly prolonged in dogs with chronic hepatitis (CH), with or without cirrhosis. Mean platelet numbers, AT and factor IX activity were significantly lower in dogs with CH plus cirrhosis, compared to dogs with other hepatopathies. D-dimers were not significantly increased in any group. Only three dogs, all with different histological diagnoses, satisfied the criteria for disseminated intravascular coagulation (DIC). Haemostatic abnormalities were primarily seen in dogs with cirrhosis and this may be due to reduced synthesis rather than increased consumption of coagulation factors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19487141/