Peer-reviewed veterinary case report
Blood clotting and platelet changes in dogs with chronic gut
By Wennogle, Sara A et al.·Published in Journal of veterinary internal medicine·2021·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy.
- Species:
- dog
Plain-English summary
A group of dogs with chronic inflammatory bowel disease (CIE) showed signs of increased blood clotting and reduced ability to break down clots compared to healthy dogs. This included 25 dogs, with some having normal protein levels and others losing protein through their intestines. Tests revealed that these dogs had higher clot strength and longer times for clots to dissolve. The findings suggest that dogs with CIE may be at risk for blood clots, which could lead to complications. Treatment options should consider these coagulation issues, and your vet may want to monitor your dog's blood health closely.
People also search for: dog inflammatory bowel disease symptoms · dog blood clotting issues · treatment for dog chronic enteropathy
Abstract
BACKGROUND: Coagulation status is poorly understood in dogs with chronic inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have not been evaluated in CIE dogs. OBJECTIVES: To assess coagulation status and fibrinolysis in normoalbuminemic CIE dogs (CIE-N) and CIE dogs with protein-losing enteropathy (CIE-PLE) compared to healthy controls (HC). To evaluate thromboelastography (TEG) variable differences between groups and for correlations with clinicopathologic data. To report platelet dynamics in CIE dogs. ANIMALS: Twenty-five client-owned dogs with CIE (n = 16 CIE-N; n = 9 CIE-PLE); 14 HC beagle dogs. METHODS: All dogs had tissue factor + tissue plasminogen activator TEG. Nine of 25 CIE dogs had whole blood impedance platelet aggregometry. The TEG variables and coagulation data were compared between all CIE vs HC dogs, CIE-N dogs vs HC, and CIE-PLE dogs vs HC. Clinicopathologic and coagulation data were available for CIE dogs and assessed for correlation to TEG variables. RESULTS: Dogs with CIE had higher maximum amplitude (MA; P < .001), longer clot lysis times (CLTs; P < .001), lower % lysis after 30 minutes (LY30; P < .001), and % lysis after 60 minutes (LY60; P < .001) compared to HC, suggesting hypercoagulability and hypofibrinolysis. When separated out, both CIE-N and CIE-PLE dogs had higher MA, longer CLT, and lower LY30 and LY60 compared to HC. Serum albumin and 25-hydroxyvitamin D (25[OH]D) concentrations, and plasma antithrombin and fibrinogen concentrations moderately correlated with MA. CONCLUSIONS AND CLINICAL IMPORTANCE: Normoalbuminemic and hypoalbuminemic CIE dogs were considered hypercoagulable based on TEG compared to HC. Some CIE dogs displayed hypofibrinolytic phenotypes on TEG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33665845/