Peer-reviewed veterinary case report
Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala.
- Journal:
- Nature neuroscience
- Year:
- 2007
- Authors:
- Stalnaker, Thomas A et al.
- Affiliation:
- Department of Anatomy and Neurobiology · United States
- Species:
- rodent
Abstract
Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17603478/