Peer-reviewed veterinary case report
Beagle with Cushing's disease had two pituitary gland problems
By Teshima, Takahiro et al.·Published in The Journal of veterinary medical science·2009·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Coexistence of corticotroph adenoma and thyrotroph hyperplasia in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old male Beagle with Cushing's disease was found to have both a pituitary tumor and an unusual growth of thyroid-stimulating cells in his pituitary gland. He had high levels of thyroid-stimulating hormone (TSH) and was treated with surgery to remove part of his pituitary gland. After the surgery, the dog's condition was confirmed to be linked to primary hypothyroidism, which can occur alongside Cushing's disease. This case is significant as it highlights a rare combination of conditions affecting the dog's pituitary gland.
People also search for: Beagle Cushing's disease treatment · dog thyroid problems symptoms · pituitary tumor in dogs
Abstract
Pituitary thyrotroph hyperplasia results from prolonged primary hypothyroidism in humans, mice and rats. In dogs with Cushing's disease, many cases have low serum thyroid hormones concentrations due to euthyroid sick syndrome. A 6-year-old castrated male Beagle diagnosed with Cushing's disease had a high serum thyroid stimulating hormone (TSH) concentration that was treated by hypophysectomy. On histological examination, the resected pituitary gland contained both a corticotroph adenoma and thyrotroph hyperplasia. The TSH-positive cell ratio in this case was greater than that of healthy Beagles. In the present case, the pituitary thyrotroph hyperplasia was probably caused by primary hypothyroidism. In conclusion, this Beagle is the first histological confirmation of the coexistence of a corticotroph adenoma and thyrotroph hyperplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19194082/