Peer-reviewed veterinary case report
Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2012
- Authors:
- Boutajangout, Allal et al.
- Affiliation:
- Department of Physiology · United States
Abstract
In the last couple of decades, substantial progress has been made in the development of transgenic mouse models developing amyloid-β deposits and/or neurofibrillary tangles. These mouse models of Alzheimer's disease and related disorders provide an excellent tool for investigating etiology, pathogenic mechanisms, and potential treatments. An essential component of their characterization is a detailed behavioral assessment, which clarifies the functional consequences of these pathologies. We have selected and refined a series of cognitive and sensorimotor tasks that are ideal for studying these models and the efficacy of various treatments.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22528113/