Peer-reviewed veterinary case report
Dog with mouth tumor made of two cancer types including melanoma
By Rodríguez, F et al.·Published in Journal of comparative pathology·2016·Institute for Animal Health, Spain·View original on PubMed →
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Original publication title: Collision Tumour of Squamous Cell Carcinoma and Malignant Melanoma in the Oral Cavity of a Dog.
- Species:
- dog
Plain-English summary
A 7-year-old male cocker spaniel was brought to the vet with a growth in his mouth and swollen lymph nodes. Tests showed he had a rare type of tumor made up of two different kinds of cancer cells: squamous cell carcinoma and malignant melanoma. Unfortunately, the cancer had spread to his lymph nodes. This case is notable because it's the first time such a collision tumor has been reported in a dog. Treatment options would typically involve surgery and possibly other therapies, but the specific outcome for this dog wasn't detailed.
People also search for: dog mouth tumor treatment · cocker spaniel oral cancer · swollen lymph nodes in dogs
Abstract
A 7-year-old, male cocker spaniel was presented with a gingival proliferative lesion in the rostral maxilla and enlargement of the regional lymph node. Morphological and immunohistochemical analysis revealed a collision tumour composed of two malignant populations, epithelial and melanocytic, with metastasis of the neoplastic melanocytes to the regional lymph node. The epithelial component consisted of trabeculae and islands of well-differentiated squamous epithelium immunoreactive to cytokeratins. The melanocytic component had a varying degree of pigmentation of polygonal and spindle-shaped cells, growing in nests or densely packed aggregates and immunolabelled with S100, melanoma-associated antigen (melan A), neuron-specific enolase and vimentin antibodies. Protein markers involved in tumorigenesis or cell proliferation (i.e. COX-2, p53, c-kit and Ki67), were overexpressed by the neoplastic cells. To the authors' knowledge, this is the first description of an oral collision tumour involving malignant melanoma and squamous cell carcinoma in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27147111/