Peer-reviewed veterinary case report
Colloidal manganese salt boosts rabies vaccine effects in mice cats
By Wang, Zongmei et al.·Published in Journal of virology·2021·State Key Laboratory of Agricultural Microbiology, China·View original on PubMed →
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Original publication title: Colloidal Manganese Salt Improves the Efficacy of Rabies Vaccines in Mice, Cats, and Dogs.
Plain-English summary
A study found that adding a new substance called colloidal manganese salt (Mn jelly) to rabies vaccines improved the immune response in dogs, cats, and mice. This means that pets receiving the Mn jelly along with their rabies shots showed a stronger defense against the rabies virus. The researchers noted that this combination helped the pets produce more immune cells and antibodies, which are crucial for fighting off infections. This could lead to better protection against rabies in pets, making the vaccine even more effective.
People also search for: dog rabies vaccine effectiveness · cat rabies shot immune response · manganese jelly rabies vaccine
Abstract
Rabies, caused by rabies virus (RABV), remains a serious threat to public health in most countries worldwide. At present, the administration of rabies vaccines has been the most effective strategy to control rabies. Herein, we evaluate the effect of colloidal manganese salt (Mn jelly [MnJ]) as an adjuvant of rabies vaccine in mice, cats, and dogs. The results showed that MnJ promoted type I interferon (IFN-I) and cytokine productionand the maturation of dendritic cells (DCs)and. Besides, MnJ serving as an adjuvant for rabies vaccines could significantly facilitate the generation of T follicular helper (Tfh) cells, germinal center (GC) B cells, plasma cells (PCs), and RABV-specific antibody-secreting cells (ASCs), consequently improve the immunogenicity of rabies vaccines, and provide better protection against virulent RABV challenge. Similarly, MnJ enhanced the humoral immune response in cats and dogs as well. Collectively, our results suggest that MnJ can facilitate the maturation of DCs during rabies vaccination, which can be a promising adjuvant candidate for rabies vaccines.Extending the humoral immune response by using adjuvants is an important strategy for vaccine development. In this study, a novel adjuvant, MnJ, supplemented in rabies vaccines was evaluated in mice, cats, and dogs. Our results in the mouse model revealed that MnJ increased the numbers of mature DCs, Tfh cells, GC B cells, PCs, and RABV-specific ASCs, resulting in enhanced immunogenicity and protection rate of rabies vaccines. We further found that MnJ had the same stimulative effect in cats and dogs. Our study provides the first evidence that MnJ serving as a novel adjuvant of rabies vaccines can boost the immune response in both a mouse and pet model.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34495701/