Peer-reviewed veterinary case report
Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand.
- Journal:
- Dalton transactions (Cambridge, England : 2003)
- Year:
- 2020
- Authors:
- Dai, Yi et al.
- Affiliation:
- Department of Chemistry · China
Abstract
Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(ii) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32242881/