Peer-reviewed veterinary case report
Chemotherapy with CCNU and vinblastine for dog mast cell tumors
By Cooper, Maureen et al.·Published in Veterinary and comparative oncology·2009·Melbourne Veterinary Specialist Centre, Australia·View original on PubMed →
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Original publication title: Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases.
- Species:
- dog
Plain-English summary
A group of 56 dogs with mast cell tumors, a type of skin cancer, underwent a combination chemotherapy treatment using CCNU and vinblastine. The treatment showed a 57% success rate in shrinking tumors that were visible, lasting about a year on average. Dogs with smaller, microscopic tumors had even better outcomes, surviving longer without the cancer worsening. While some dogs experienced mild side effects, the overall treatment was well tolerated. This chemotherapy approach could be a good option for dogs diagnosed with mast cell tumors.
People also search for: dog mast cell tumor treatment · CCNU vinblastine side effects · chemotherapy for dog cancer
Abstract
The purpose of this study was to evaluate the efficacy and toxicity of a CCNU and vinblastine chemotherapy protocol for canine mast cell tumours. Fifty-seven tumours in 56 dogs were evaluated, 37 had macroscopic disease and 20 had microscopic disease. A 57% response rate was seen in dogs with macroscopic disease for a median duration of 52 weeks. Dogs with macroscopic disease had a median progression free survival time (PFST) of 30 weeks and a median overall survival time (OST) of 35 weeks. Dogs with microscopic disease had a median PFST of 35 weeks and a median OST of 48 weeks. Toxicity was recorded in 54% of the dogs treated, with the majority of events being mild. This chemotherapy protocol appears to be well tolerated and should be considered for canine mast cell tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19691648/