Peer-reviewed veterinary case report
Treatment options for inflammatory colorectal polyps in miniature
By Murakami, Akira et al.·Published in Journal of the American Animal Hospital Association·2018·Faculty of Applied Biological Sciences, Japan·View original on PubMed →
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Original publication title: Combination Chlorambucil/Firocoxib or Chlorambucil/Prednisolone Treatment for Inflammatory Colorectal Polyps in Miniature Dachshunds.
- Species:
- dog
Plain-English summary
Six miniature dachshunds with inflammatory colorectal polyps (ICRP), which can cause symptoms like diarrhea and straining to defecate, were treated with a combination of chlorambucil and either firocoxib or prednisolone. By the end of the study, five of the six dogs showed improvement in their symptoms, with four responding well to the chlorambucil and firocoxib combination. One dog did develop a blood issue after long-term treatment, but it wasn't clear if the medication caused it. Overall, the combination treatments appeared effective and safe for managing ICRP in these dogs.
People also search for: miniature dachshund inflammatory bowel disease treatment · dog diarrhea medication · chlorambucil for dogs · firocoxib side effects in dogs
Abstract
Inflammatory colorectal polyps (ICRP), which are more commonly recognized in miniature dachshunds, are thought to represent an immune-mediated disease. This retrospective case series describes six miniature dachshunds with refractory ICRP, who were treated with chlorambucil (CLB) combined with firocoxib or prednisolone. Improvement in clinical manifestations was seen in five of the six dogs by the end of the study period; four were treated with CLB/firocoxib and one with CLB/prednisolone. One dog had nonregenerative anemia after 23 mo of treatment with CLB, but whether there was a causative relationship was unclear. No severe adverse events were observed during treatment in the remaining five dogs. CLB in combination with firocoxib or prednisolone appears to be an effective alternative treatment for ICRP in dogs. Further studies are needed to confirm the effectiveness and long-term complications of CLB treatment for ICRP in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29558217/