Peer-reviewed veterinary case report
Treating cystic uterine infection in bitches with dopamine
By Corrada, Y et al.·Published in Theriogenology·2006·Small Animal Clinic & Imaging Diagnosis Service·View original on PubMed →
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Original publication title: Combination dopamine agonist and prostaglandin agonist treatment of cystic endometrial hyperplasia-pyometra complex in the bitch.
Plain-English summary
A group of 29 female dogs diagnosed with cystic endometrial hyperplasia-pyometra (CEH-P), a serious uterine condition, received a combination treatment of cabergoline and cloprostenol for 7 to 14 days. Most of the dogs showed significant improvement within just a couple of days, with 24 out of 29 fully recovering by Day 14. While some experienced mild digestive upset, the treatment effectively reduced uterine swelling and allowed one dog to successfully become pregnant after treatment. This combination therapy was found to be both safe and effective for treating CEH-P in breeding dogs.
People also search for: dog pyometra treatment · cystic endometrial hyperplasia in dogs · cabergoline for dogs · cloprostenol side effects in dogs
Abstract
Cystic endometrial hyperplasia-pyometra (CEH-P) complex is a progesterone-dependent disease that requires medical treatment in bitches intended for breeding. To test the efficacy and safety of a combined protocol and to assess the effect of age, stage of cycle, previous steroid hormone administration and parity on treatment, 29 bitches diagnosed with CEH-P complex were treated daily with cabergoline 5 microg/kg PO and cloprostenol 1 microg/kg SC for 7-14 days, along with supportive antibiotic and hydration therapies. Before treatment, and on Days 3, 7 and 14, all bitches were evaluated clinically and uterine horn diameter measured during trans-abdominal ultrasonography. Twenty-four of 29 bitches were cured by either Day 7 or 14. Nine bitches had mild digestive side effects. Clinical signs related to pyometra began to improve markedly as early as Day 2 of treatment. Uterine diameters decreased (P < 0.05) by Day 3 of treatment, and continued to gradually decrease, reaching normal size by Day 14. Relapses occurred in 6 of 29 cases. Pregnancy was achieved in one of the two young bitches bred after treatment. No significant relationships were found between success rate and age, stage of the estrous cycle, previous hormone administration or parity. Although no variables affecting treatment results could be identified, this combination of compounds was found to be an efficient and safe for treatment of CEH-P.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16458958/