Peer-reviewed veterinary case report
Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2015
- Authors:
- Rullas, Joaquín et al.
- Affiliation:
- Diseases of the Developing World · Spain
- Species:
- rodent
Abstract
We report here a dehydropeptidase-deficient murine model of tuberculosis (TB) infection that is able to partially uncover the efficacy of marketed broad-spectrum β-lactam antibiotics alone and in combination. Reductions of up to 2 log CFU in the lungs of TB-infected mice after 8 days of treatment compared to untreated controls were obtained at blood drug concentrations and time above the MIC (T>MIC) below clinically achievable levels in humans. These findings provide evidence supporting the potential of β-lactams as safe and mycobactericidal components of new combination regimens against TB with or without resistance to currently used drugs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25987618/