Peer-reviewed veterinary case report
Safe and effective combined vaccine for four major cat viruses
By Kanellos, Theo et al.·Published in Journal of feline medicine and surgery·2008·Agricultural University of Athens·View original on PubMed →
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Original publication title: Combined administration in a single injection of a feline multivalent modified live vaccine against FHV, FCV, and FPLV together with a recombinant FeLV vaccine is both safe and efficacious for all four major feline viral pathogens.
- Species:
- cat
Plain-English summary
A group of cats received a combined vaccine that protects against four major viral infections: feline herpesvirus, calicivirus, panleukopenia virus, and feline leukemia virus (FeLV). The mixed vaccine was tested for safety and effectiveness, and it showed no negative effects on the immune response or overall health of the cats. The cats remained well-protected against these viruses after receiving the combined shot. This means that pet owners can safely vaccinate their cats against multiple diseases in one visit, making it easier to keep their pets healthy.
People also search for: cat vaccine safety · feline leukemia vaccine effectiveness · combined cat vaccine benefits
Abstract
Nobivac Tricat, a lyophilised trivalent modified live attenuated vaccine is routinely used to protect cats against three commonly diagnosed feline viral pathogens namely herpesvirus, calicivirus and panleukopenia virus. The recognition of feline leukaemia virus (FeLV) as an important viral pathogen has prompted the development of an efficacious liquid recombinant subunit FeLV vaccine (p45 envelope protein). Lyophilised Tricat vaccine was dissolved in the liquid FeLV vaccine and no detectable deleterious effect on the titre of any of the live virus components was observed after 2h incubation. In vivo studies where the vaccines were mixed in the same syringe prior to inoculation showed no alteration to the safety profile assessed by repeat and overdose studies. Serological comparisons of the modified live viral antibody titres showed no evidence of reduced responses following administration of the mixed products. Challenge studies using pathogenic herpesvirus and FeLV revealed no difference in the degree of clinical protection. This paper shows that neither safety nor efficacy is adversely affected as a result of mixing the two vaccines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18448375/