Peer-reviewed veterinary case report
Combined Gamma-Rays and Carbon-12 Nuclei Irradiation Modulates Brain Chemokine and Cytokine Production and Improves Spatial Learning in Tau P301S, but not 5xFAD Mouse Line.
- Journal:
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Year:
- 2023
- Authors:
- Kokhan, V S et al.
- Affiliation:
- Serbsky Federal Medical Research Centre for Psychiatry and Narcology
- Species:
- rodent
Abstract
Earlier we showed the pro-cognitive effect of low doses of combined irradiation (including heavy charged particles) on Wistar rats. In the present work we studied the effect of irradiation (gamma-rays, 0.24 Gy; carbon-12, 0.18 Gy, 400 MeV/nucleon) on the course of neurodegenerative process using Tau P301S and 5xFAD transgenic mice lines, experimental models of Alzheimer's disease. Irradiation led to an increase in pro- and anti-inflammatory cytokines and chemokines (IL-2, IL-6, IL-10, KC) in Tau P301S mice, but not in 5xFAD. At the same time, only the Tau P301S line was found to exhibit radiation-induced improvement in spatial learning.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37833582/