Peer-reviewed veterinary case report
Combined photothermal-photodynamic therapy by indocyanine green loaded polydopamine nanoparticles enhances anti-mammary gland tumor efficacy.
- Journal:
- Journal of materials chemistry. B
- Year:
- 2022
- Authors:
- Liu, Xu et al.
- Affiliation:
- College of Biomedical Engineering · China
Abstract
Various nano-targeted drug delivery systems have been developed for combined photothermal-photodynamic (PTT-PDT) treatment of tumors due to better outcomes compared with monomodality therapy. Here, we constructed a facile two-step method without core templates to obtain indocyanine green (ICG) loaded-hyaluronic acid (HA) surface-coated polydopamine nanoparticles (IIPH). The prepared nanoparticles demonstrated an excellent photothermal conversion capacity and efficient singlet oxygen production. Bothandstudies proved that IIPH could significantly inhibit the growth of tumor by PTT-PDT combinational treatment. All the results indicated that IIPH NPs hold great potential to be utilized as a new photothermal-photodynamic composite for cancer treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35642529/