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Peer-reviewed veterinary case report

Combined treatment of ocular squamous cell carcinoma in a horse, using radiofrequency hyperthermia and interstitial 198Au implants.

Journal:
Journal of the American Veterinary Medical Association
Year:
1990
Authors:
Wilkie, D A & Burt, J K
Affiliation:
Department of Veterinary Clinical Sciences · United States
Species:
horse

Plain-English summary

A horse with a type of eye cancer called unilateral ocular squamous cell carcinoma was successfully treated using two methods together: radiofrequency hyperthermia (a technique that heats the tissue) and interstitial radiotherapy (using small radioactive implants). The horse received the radioactive implants, which delivered a specific dose of radiation to the tumor, and underwent the heating treatment three times, along with the radiotherapy twice. After this combined treatment, the tumor completely disappeared, and there have been no eye-related problems since. Overall, the treatment worked very well.

Abstract

Unilateral ocular squamous cell carcinoma in a horse was treated effectively with a combination of repeated radiofrequency hyperthermia and interstitial radiotherapy. These 2 modalities of treatment are synergistic. Interstitial irradiation was achieved, using 198Au implants to deliver a total dose of approximately 5,000 rads/implant over an area of 1 cm2. Radio frequency hyperthermia was repeated 3 times, and radiotherapy was used twice. Treatment resulted in complete regression of the tumor, and ocular complications have not been seen.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/2351606/