Peer-reviewed veterinary case report
Common Marmoset Model of α-Synuclein Propagation.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2021
- Authors:
- Masuda-Suzukake, Masami et al.
- Affiliation:
- Tokyo Metropolitan Institute of Medical Science · Japan
Abstract
The propagation of assembled α-synuclein (αS) is key to understanding the pathological mechanisms of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Here we describe a nonhuman primate model of αS propagation using common marmosets (Callithrix jacchus) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its propagation three months after the injection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34043199/