Peer-reviewed veterinary case report
IV acid suppressants compared for raising stomach pH in dogs
By Kuhl, Amanda et al.·Published in Journal of veterinary internal medicine·2020·Department of Small Animal Clinical Sciences·View original on PubMed →
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Original publication title: Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs.
- Species:
- dog
Plain-English summary
A group of healthy Beagles were given different intravenous (IV) acid suppressants to see which one worked best at raising stomach acidity levels. The treatments included esomeprazole, pantoprazole, and famotidine, and all three were effective in increasing the stomach pH. However, esomeprazole and famotidine were found to be more effective than pantoprazole for the first three days of treatment. This suggests that if a dog is suffering from stomach ulcers or bleeding, famotidine or esomeprazole might be better options for managing their condition.
People also search for: dog stomach ulcer treatment · IV famotidine for dogs · esomeprazole for dog ulcers
Abstract
BACKGROUND: Upper gastrointestinal (GI) ulceration and bleeding in critically ill dogs can cause severe anemia and increase morbidity. Acid suppressants using proton pump inhibitors or histamine-2 receptor blockers administered IV is commonly recommended. HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of IV administered esomeprazole, pantoprazole, and famotidine constant rate infusion (CRI) on increasing the intragastric pH of dogs. We hypothesized that esomeprazole and famotidine CRI would provide superior acid suppression compared to pantoprazole and reach pH goals for the treatment of GI bleeding. ANIMALS: Nine healthy research Beagles. METHODS: Randomized, 3-way crossover. Dogs received pantoprazole or esomeprazole at 1 mg/kg IV q12h and famotidine with a loading dose of 1 mg/kg followed by 8 mg/kg IV CRI daily for 3 consecutive days. The intragastric pH was recorded at baseline and for 72 hours of treatment. The mean pH and the mean percentage time (MPT) the intragastric pH was ≥3 or ≥4 were compared among and within treatment groups. RESULTS: Significant increases in mean pH (P < 0.0001), MPT ≥3 (P < 0.001), and MPT ≥4 (P = 0.0006) were noted over time with all 3 treatments. The time effect did not differ by treatment for mean pH, MPT ≥3, and MPT ≥4 (P = .29, .56, and .37, respectively); however, only esomeprazole and famotidine CRI achieved the goals established for the treatment of gastroduodenal ulceration in people. CONCLUSIONS AND CLINICAL IMPORTANCE: Famotidine CRI and esomeprazole might be superior acid suppressants compared to standard doses of pantoprazole for the first 72 hours of treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32020689/