Peer-reviewed veterinary case report
Carperitide vs furosemide effects on heart pressure in dogs
By Suzuki, S et al.·Published in Journal of veterinary internal medicine·2013·Department of Veterinary Surgery, Japan·View original on PubMed →
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Original publication title: Comparative effect of carperitide and furosemide on left atrial pressure in dogs with experimentally induced mitral valve regurgitation.
- Species:
- dog
Plain-English summary
A group of healthy 3-year-old Beagle dogs with surgically induced mitral valve disease (a heart condition) were given either carperitide or furosemide to see which medication better reduced left atrial pressure, a measure of heart function. Both medications successfully lowered the pressure, but carperitide also resulted in lower levels of certain hormones related to heart stress. This suggests that carperitide may be a beneficial treatment option for dogs with mitral valve disease, potentially causing fewer side effects than furosemide. Further research is needed to confirm these findings in dogs with naturally occurring heart disease.
People also search for: dog mitral valve disease treatment · carperitide for dogs heart problems · furosemide side effects in dogs
Abstract
BACKGROUND: The effects of carperitide on left atrial pressure (LAP) in dogs with mitral valve disease (mitral regurgitation, MR) have not been documented. OBJECTIVE: The objective was to compare the short-term effects of carperitide versus furosemide on LAP and neurohumoral factors in MR dogs. ANIMALS: Six healthy Beagle dogs weighing 9.8-12.6 kg (2 males and 4 females; aged 3 years) were used. METHODS: Experimental, randomized, cross-over, and interventional study. Carperitide 0.1 μg/kg/min or furosemide 0.17 mg/kg/h (1 mg/kg/6 h) was administered to dogs with surgically induced MR for 6 hours, and after a 14 day wash-out period, the other drug was administered. LAP, plasma renin activity, plasma aldosterone, and echocardiographic variables were measured. RESULTS: Left atrial pressure was decreased similarly after the administration of carperitide 0.1 μg/kg/min and furosemide 0.17 mg/kg/h (1 mg/kg/6 h) compared with baseline in dogs with MR (Baseline 14.75 ± 3.74 mmHg, carperitide 10.24 ± 4.97 mmHg, P < .01, furosemide 10.77 ± 5.06 mmHg, P < .05). Plasma renin activity and plasma aldosterone were significantly lower after the administration of carperitide than after the administration of furosemide (P < .05, respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: Carperitide significantly decreased LAP in dogs with acute MR caused by experimental chordal rupture. Carperitide can have additional benefits from the viewpoint of minimal activation of neurohumoral factors in the treatment of dogs with MR. Additional studies in dogs with spontaneous disease are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23952288/