Peer-reviewed veterinary case report
Amlodipine lowers left atrial pressure in dogs with mitral valve
By Suzuki, Shuji et al.Ā·Published in BMC veterinary researchĀ·2012Ā·Department of Veterinary Surgery, JapanĀ·View original on PubMed ā
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Original publication title: Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation.
- Species:
- dog
Plain-English summary
A group of five Beagle dogs with a heart condition called mitral regurgitation (MR) were given either amlodipine or benazepril to see which medication could better lower pressure in the left atrium of the heart. After a week, the dogs taking amlodipine showed a significant drop in left atrial pressure compared to those on benazepril, which did not lower the pressure at all. This suggests that amlodipine might be a more effective option for dogs with severe MR. However, more research is needed to fully understand the long-term effects and safety of amlodipine in dogs with heart issues.
People also search for: dog mitral regurgitation treatment Ā· amlodipine for dogs heart problems Ā· benazepril side effects in dogs
Abstract
BACKGROUND: One of the purposes of treatment for dogs with mitral regurgitation (MR) is lowering left atrial pressure (LAP). There has been few study of the amlodipine in dogs with MR and amlodipine's effect on LAP has not been fully evaluated in a quantitative manner because of difficulties in directly measuring LAP. The objective of our study was to compare the short-term effects of amlodipine (0.2 mg/kg PO q12h) vs benazepril (0.5 mg/kg PO q12h), on LAP and echocardiographic parameters in five beagle dogs with experimentally-induced MR. LAP of eight dogs that has own control were measured using radiotelemetry system at baseline and again on days 1, 2, 3, 4, 5, 6, 7 of the drug administration. RESULTS: Mean LAP decreased significantly after amlodipine (11.20 ± 4.19 mmHg vs 14.61 ± 3.81 mmHg at baseline, p < .01) but not after benazepril treatment (13.19 ± 3.47 mmHg, p > .05). LAP was lower after 7 days of amlodipine treatment than after 7 days of benazepril treatment. Significant reduction was seen for the first time 4 days after the administration amlodipine. The rate of the maximal area of the regurgitant jet signals to the left atrium area (ARJ/LAA) of the amlodipine treatment was significantly lower (p < .05) after 7 days compared to baseline. Other echocardiographic parameters did not change significantly. CONCLUSIONS: LAP was significantly decreased after amlodipine treatment in dogs with surgically-induced MR but not after benazepril treatment. Although this study did not focus on adverse effects, amlodipine may be an effective drug for helping the patients with acute onset of severe MR, such as rupture of chordae tendinae or end stage patients were the LAP is likely to be elevated. Additional studies in clinical patients with degenerative mitral valve disease and acute chordal rupture are warranted because the blood-pressure lowering effects of amlodipine can decrease renal perfusion and this can further activate the RAAS.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22989022/