Peer-reviewed veterinary case report
Weekly Advocate treatment works better for dogs with demodicosis
By Fourie, Josephus J et al.·Published in Parasitology research·2009·ClinVet International·View original on PubMed →
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Original publication title: Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate) against generalised demodicosis in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with generalized demodicosis (a skin condition caused by mites) was treated with a topical medication called Advocate, which contains imidacloprid and moxidectin. The dogs were divided into two groups: one received treatment every week for 15 weeks, while the other was treated every 28 days for 12 weeks. The dogs that received weekly treatments showed significantly better results, with fewer skin lesions, more hair regrowth, and even weight gain compared to those treated less frequently. The weekly treatment was found to be safe, with only minor skin reactions noted in a couple of dogs.
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Abstract
This laboratory study compared the efficacy of two treatment regimens using an imidacloprid (10%)/moxidectin (2.5%) topical formulation (Advocate, Bayer) on dogs with generalised demodicosis. Sixteen dogs were randomly allocated to two equal groups. One group was treated at 28-day intervals for 12 weeks and the second group at weekly intervals for 15 weeks. Mite numbers were estimated and demodectic lesions were evaluated on each dog before treatment and at approximately 28-day intervals thereafter. Consistently greater reduction in mite numbers was recorded for the weekly treatment regimen. Dogs treated at weekly intervals exhibited markedly fewer clinical signs and greater hair regrowth and weight gain than those treated at 28-day intervals. To assess the safety of a weekly treatment interval in dogs, a study was done in which the investigational compound was administered at weekly intervals at five times the recommended dose for a period of 16 consecutive weeks. Apart from transient erythema at the site of administration in one dog and scaliness of the skin in another, no clinical signs of toxicity could be observed. Assessment of 27 blood parameters indicated that only basophils were outside the reference values on days +13 and +69, during the safety trial period.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19575232/