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Peer-reviewed veterinary case report

Comparative evaluation of PCR in Ziehl-Neelsen stained smears and PCR in tissues for diagnosis of Mycobacterium avium subsp. paratuberculosis.

Journal:
Indian journal of experimental biology
Year:
2010
Authors:
Coelho, A C et al.
Affiliation:
Department of Veterinary Sciences

Abstract

Thirty six tissues from sheep, previously diagnosed with paratuberculosis, were tested by PCR in positive Ziehl-Neelsen staining smears of tissues, and PCR in tissues targeting IS900 specific for Mycobacterium avium subsp. paratuberculosis. DNA amplification was achieved in 33.3% Ziehl-Neelsen smears, and in 61.1% tissue samples. Combination of both techniques found 66.7% samples as positive. Combination of techniques would, therefore, increase the sensitivity of diagnosis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/21506505/