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Peer-reviewed veterinary case report

Cat with bone cancer in toe and lung metastasis studied with tumor

By Lyvia Cabral Ribeiro Carvalho et al.·Published in Heliyon·2025·Programa de Pós-Graduação em Medicina Veterinária - Clínica e Reprodução Animal, Universidade Federal Fluminense, Niterói, RJ, Brazil; Corresponding author. Av. Almirante Ary Parreiras, n.507, Vital Brazil, Niterói, RJ, Faculdade de Veterinária, Universidade Federal Fluminense, 24230-320, Brazil., GB·View original on DOAJ

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Original publication title: Comparative immunohistochemical evaluation between primary and metastatic lesion in a feline osteosarcoma - A case report

Species:
cat
Movement & jointsCats

Plain-English summary

A 12-year-old cat was diagnosed with osteosarcoma, a type of bone cancer, affecting her toe. Over a year and a half, the cancer spread to her lungs and caused additional growths on her toes. Researchers studied both the original tumor and the metastatic lesions to understand why this type of cancer behaves aggressively in cats. The findings highlighted both similarities and differences in the tumors, which could help in future treatments. Unfortunately, the prognosis for cats with this condition remains serious due to the aggressive nature of the disease.

People also search for: cat osteosarcoma symptoms · feline bone cancer treatment · cat lung metastasis signs

Abstract

Feline primary bone tumors are rare. Still, osteosarcoma (OSA) composes almost 80 % of malignant bone tumors in cats, affecting mostly elder feline individuals. Many differences are observed between canine and feline OSA regarding radiographic image and tumoral behavior, especially metastasis development. This case reports a cat diagnosed with digital osteosarcoma who developed pulmonary metastasis and other digital lesions over one year and half later. Simultaneous immunohistochemical analysis from both primary and metastatic tumoral tissues was performed using diagnostic and prognostic biomarkers panel for bone tumors in order to better understand such aggressive behavior in a feline patient. Similarities and differences from both lesions results revealed intrinsic mechanisms promoting osteosarcoma invasion in this cat.

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Original publication on DOAJ: https://doi.org/10.1016/j.heliyon.2024.e40959